Advant Tablets 8Mg (1 Strip = 7 Tablets)
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II)
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects thatinclude vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is, therefore, independent of the pathways for angiotensin II synthesis.
Purpose
Hypertension
Ingredients
Candesartan Cilexetil
Warnings
Hypotension may occur during treatment with candesartan in heart failure patients. It may also occur in hypertensive patients with intravascular volume depletion. Caution is advised to be observed when initiating therapy and correction of hypovolaemia is advised to be attempted.
Candesarten may increase blood urea and serum creatinine in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney.
During dialysis the blood pressure may be particularly sensitive to AT1- receptor blockade as a result of reduced plasma volume and activation of the renin-angiotensin-aldosterone system. Therefore, candesartan is advised to be carefully titrated with thorough monitoring of blood pressure in patients on haemodialysis.
Side Effects
Body as a Whole: asthenia, fever.Central and Peripheral Nervous System: paresthesia, vertigo.Gastrointestinal System Disorder: dyspepsia, gastroenteritis.Heart Rate and Rhythm Disorders: tachycardia, palpitation.Metabolic and Nutritional Disorders: creatine phosphokinase increased, hyperglycemia, hypertriglyceridemia, hyperuricemia.Musculoskeletal System Disorders: myalgia.Platelet/Bleeding-Clotting Disorders: epistaxis.Ps ychiatric Disorders : anxiety, depres sion, somnolence.Respiratory System Disorders: dyspnea.Skin and Appendages Disorders: rash, increased sweating.Urinary System Disorders: hematuria.
Storage Instructions
Store this medicine at room temperature, away from direct light and heat.
| Brand | Getz |
| Status | Active |
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