Aldomet Tablets 250Mg (1 Strip = 10 Tablets)
It appears that several mechanisms of action account for the clinically useful effects of methyldopa and the current...
It appears that several mechanisms of action account for the clinically useful effects of methyldopa and the current generally accepted view is that its principal action is on the central nervous system. The antihypertensive effect of methyldopa is probably due to its metabolism to alpha-methylnoradrenaline, which lowers arterial pressure by stimulation of central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity. Methyldopa has been shown to cause a net reduction in the tissue concentration of serotonin, dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline).
Purpose
Hypertension
Ingredients
Methyldopa
Warnings
Some patients taking methyldopa experience clinical edema or weight gain which may be controlled by use of a diuretic. Methyldopa is advised to not be continued if edema progresses or signs of heart failure appear.
It is important to recognize that a positive Coombs test, hemolytic anemia, and liver disorders may occur with methyldopa therapy.
Methyldopa is advised to be used with caution in patients with a history of previous liver disease or dysfunction .
Side Effects
Digestive: Pancreatitis, colitis, vomiting, diarrhea, sialadenitis, sore or “black†tongue, nausea, constipation, distension, flatus, dryness of mouth.Endocrine: Hyperprolactinemia.Hematologic: Bone marrow depression, leukopenia, granulocytopenia, thrombocytopenia, hemolytic anemia; positive tests for antinuclear antibody, LE cells, and rheumatoid factor, positive Coombs test.Hepatic: Liver disorders including hepatitis, jaundice, abnormal liver function tests .Hypersensitivity: Myocarditis, pericarditis, vasculitis, lupus-like syndrome, drug-related fever, eosinophilia.
Storage Instructions
Store this medicine at room temperature, away from direct light and heat.
| Brand | OBS |
| Status | Active |
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