Apiban Tablets 5Mg (1 Strip = 10 Tablets)

Apixaban is a potent, oral, reversible, direct and highly selective active site inhibitor of factor Xa

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SKU: APIBAN_5_MG_30_TABLETS_NV

Category: Medicines

Apixaban is a potent, oral, reversible, direct and highly selective active site inhibitor of factor Xa. It does not require antithrombin III for antithrombotic activity. Apixaban inhibits free and clot-bound factor Xa and prothrombinase activity. Apixaban has no direct effects on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting factor Xa, Apixaban prevents thrombin generation and thrombus development.

Purpose

Stroke

Ingredients

Apixaban

Warnings

Premature discontinuation of any oral anticoagulant, including Apixaban, increases the risk of thrombotic events. To reduce this risk, consider coverage with another anticoagulant if Apixaban is discontinued for a reason other than pathological bleeding or completion of a course of therapy.
Epidural or spinal hematomas may occur in patients treated with Apixaban who are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures.
Apixaban increases the risk of bleeding and can cause serious, potentially fatal, bleeding. Advise patients of signs and symptoms of blood loss and to report them as soon as possible or go to an emergency room. Discontinue Apixaban in patients with active pathological hemorrhage .

Side Effects

Common: Haemorrhage, haematoma, epistaxis, gastrointestinal haemorrhage, rectal haemorrhage, gingival bleeding, haematuria and contusion. Uncommon: Pruritus, eye haemorrhage (including conjunctival haemorrhage), haemoptysis, haematochezia, abnormal vaginal haemorrhage, urogenital haemorrhage, occult blood positive, traumatic haemorrhage, post procedural haemorrhage and incision site haemorrhage. Rare: Brain haemorrhage and respiratory tract haemorrhage .