Co-Renitec Tablets 10Mg/25Mg (1 Strip = 10 Tablets)
Enalapril maleate : Enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ACE)
Enalapril maleate : Enalapril, after hydrolysis to enalaprilat, inhibits angiotensin-converting enzyme (ACE). The mechanism through which enalapril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. In patients treated with enalapril maleate plus a thiazide diuretic, there was essentially no change in serum potassium. Hydrochlorothiazide : Hydrochlorothiazide is a thiazide diuretic. It affects the distal renal tubular mechanism of electrolyte reabsorption. Hydrochlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.
Purpose
Hypertension
Ingredients
Enalapril Maleate + Hydrochlorothiazide
Warnings
If you have a kidney problem (including kidney transplantation). These may lead to higher levels of potassium in your blood which can be serious. Your doctor may need to adjust your dose of Enalapril or monitor your blood level of potassium.
If you have low blood pressure (you may notice this as faintness or dizziness, especially when standing) .
If you have diabetes and are taking antidiabetic agents or insulin to control your diabetes; you is advised to closely monitor your blood for low blood glucose levels especially during the first month of treatment. The level of potassium in your blood can also be higher.
Side Effects
• Headache, depression, fainting • low blood pressure (which may make you feel dizzy when you stand up) • chest pain • heart rhythm changes, fast heart beat • shortness of breath • diarrhoea, pain around your stomach area (abdomen), changes in taste, feeling tired • rash • increased blood potassium level, increases in serum creatinine (both are usually detected by a test) • low levels of potassium in the blood, which can cause muscle weakness, twitching or abnormal heart rhythm, increased levels of cholesterol, increased levels of triglycerides, increased levels of uric acid in the blood • muscle cramps.
Storage Instructions
Store this medicine at room temperature, away from direct light and heat.
| Brand | OBS |
| Status | Active |
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