Detrusitol Tablets 2Mg (1 Box = 2 Strips) (1 Strip = 14 Tablets)

Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors

PKR 1649.65

PKR 1567.17

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SKU: DETRUSITOL_TABLETS_2_MG_28S_NV

Category: Medicines

Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of 5-hydroxymethyl tolterodine (5-HMT), the major pharmacologically active metabolite. 5-HMT, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and 5-HMT exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels.

Purpose

Urinary Incontinence

Ingredients

Tolterodine L-Tartrate

Warnings

Administer Tolterodine Tartrate with caution to patients with clinically significant bladder outflow obstruction because of the risk of urinary retention .
Administer Tolterodine Tartrate with caution in patients with gastrointestinal obstructive disorders because of the risk of gastric retention. Tolterodine Tartrate , like other antimuscarinic drugs, may decrease gastrointestinal motility and is advised to be used with caution in patients with conditions associated with decreased gastrointestinal motility (e.g., intestinal atony) .
Tolterodine Tartrate is associated with anticholinergic central nervous system (CNS) effects including dizziness and somnolence . Patients is advised to be monitored for signs of anticholinergic CNS effects, particularly after beginning treatment or increasing the dose. Advise patients not to drive or operate heavy machinery until the drug''''s effects have been determined. If a patient experiences anticholinergic CNS effects, dose reduction or drug discontinuation is advised to be considered.