Evopride Plus Tablets 1/500Mg (1 Strip = 10 Tablets)

Glimepiride: Glimepiride is a third generation sulphonylurea

PKR 317.00

PKR 301.15

You save: PKR 15.85

Quantity:

SKU: EVOPRIDE_PLUS_TABLETS_1500_MG_30S_NV

Category: Medicines

Glimepiride: Glimepiride is a third generation sulphonylurea. The primary mechanism of action of glimepiride appears to be dependent on stimulating the release of insulin from functioni ng pancreatic beta cells. In addition, extrapancreatic effects (e.g. reduction of basal hepatic glucose production and increased peripheral tissue sensitivity to insulin and glucose uptake) may also play role in the activity of glimepiride.Metformin HCl: Metformin hydrochloride is a biguanide anti-diabetic, which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its mode of action is thought to be multifactoral and includes delayed uptake of glucose from the intestinal tract, increased peripheral glucose utilization mediated by increased insulin sensitivity and inhibition of increased hepatic and renal gluconeogenesis.

Purpose

Diabetes

Ingredients

Glimepiride, Metformin HCl

Warnings

Lactic acidosis is rare, but serious metabolic complication that can occur due to metformin accumulation. The incidence of lactic acidosis can and is advised to be reduced by assessing also other associated risk factors such as poorly controlled diabetes, ketosis, prolonged fasting, excessive alcohol intake, hepatic insufficiency and any condition associated with hypoxia.
As metformin is excreted by the kidney, serum creatinine levels is advised to be determined before initiating treatment and regularly thereafter.
Safety and effectiveness of the drug in children have not been established.

Side Effects

Diarrhea, vomiting, metallic taste, rash, isolated transaminase elevations, cholestatic jaundice, allergic skin reactions, photosensitivity reactions, leukopenia, agranulocytosis, thrombocytopenia, hemolyticanemia, aplastic anemia, pancytopenia and blurred vision. Glimepiride appears to be associated with a low incidence of hypoglycemia.