Femara Tablets 2.5Mg (1 Box = 3 Strips) (1 Strip = 10 Tablets)
Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of...
Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult nontumor- and tumor-bearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors. In contrast to ovariectomy, treatment with letrozole does not lead to an increase in serum FSH. Letrozole selectively inhibits gonadal steroidogenesis but has no significant effect on adrenal mineralocorticoid or glucocorticoid synthesis.
Purpose
Cancer
Ingredients
Letrozole
Warnings
Use of Letrozole may cause decreases in bone mineral density (BMD). Lets is a potent oestrogen-lowering agent. Women with a history of osteoporosis and/or fractures, or who are at increased risk of osteoporosis, is advised to have their bone mineral density formally assessed prior to the commencement of adjuvant and extended adjuvant treatment and monitored during and following treatment with letrozole is required for patients with renal insufficiency with creatinine clearance =10 ml/min. Caution is there if creatinine clearance less than 10ml/minute.
Consideration is advised to be given to monitoring serum cholesterol.
Subjects with cirrhosis and severe hepatic impairment who were dosed with 2.5 mg of Letrozole experienced approximately twice the exposure to Letrozole as healthy volunteers with normal liver function. Therefore, a dose reduction is recommended for this patient population.
Side Effects
Common or very common: Abdominal pain ,alopecia ,anorexia,appetite increase, arthralgia,bone fracture, Constipation, depression, diarrhea, dizziness, dry skin, dyspepsia, fatigue, headache, hot flushes, hypercholesterolaemia, hypertension, increased sweating, musculoskeletal pain, nausea, osteoporosis, peripheral oedema, rash, vaginal bleeding,vomiting, weight changes. Uncommon: Anxiety, arthritis, blurred vision, breast pain, cardiac events, cataract, cerebrovascular events, cough, Dysaesthesia, dyspnea, eye irritation, general oedema, insomnia, leucopenia, memory impairment, mucosal Dryness, palpitation, pruritus, pyrexia, stomatitis, tachycardia, taste disturbance, thrombophlebitis, tumour pain, urinary frequency,urinary-tract infection,urticaria. vaginal discharge. Rare: Arterial thrombosis . pulmonary embolism. Frequency not known: Hepatitis ,toxic epidermal necrolysis.
Storage Instructions
Store this medicine at room temperature, away from direct light and heat.
| Brand | Novartis |
| Status | Active |
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