Fonaz Capsule 150Mg (1 Box = 1 Capsule)

Fluconazole is a triazole antifungal agent

PKR 170.00

PKR 161.50

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SKU: FONAZ_CAPSULES_NV

Category: Medicines

Fluconazole is a triazole antifungal agent. Its primary mode of action is the inhibition of fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylation, an essential step in fungal ergosterol biosynthesis. The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell membrane and may be responsible for the antifungal activity of fluconazole. Fluconazole has been shown to be more selective for fungal cytochrome P-450 enzymes than for various mammalian cytochrome P-450 enzyme systems.

Purpose

Fungal Infection

Ingredients

Fluconazole

Warnings

Fluconazole is advised to be administered with caution to patients with renal dysfunction .
Fluconazole have been associated with rare cases of serious hepatic toxicity including fatalities, primarily in patients with serious underlying medical conditions. In cases of fluconazole associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex or age of patient has been observed. Fluconazole hepatotoxicity has usually been reversible on discontinuation of therapy.
Fluconazole is advised to be administered with caution to patients with potentially proarrhythmic conditions. Coadministration of other medicinal products known to prolong the QT interval and which are metabolised via the cytochrome P450 (CYP) 3A4 are contraindicated.

Side Effects

Common side effects (may affect up to 1 in 10 people) are: - Headache - stomach discomfort, diarrhoea, feeling sick, vomiting - increases in blood tests of liver function - rash . Uncommon side effects (may affect up to 1 in 100 people) are: - Reduction in red blood cells which can make skin pale and cause weakness or breathlessness - decreased appetite- inability to sleep, feeling drowsy - fit, dizziness, sensation of spinning, tingling, pricking or numbness, changes in sense of taste - constipation, difficult digestion, wind, dry mouth - muscle pain - liver damage and yellowing of the skin and eyes (jaundice) - wheals, blistering (hives), itching, increased sweating - tiredness, general feeling of being unwell, fever.