Genticyn Im/Iv Injection 40Mg (1 Box = 3 Ampoules)
Gentamicin, an aminoglycoside antibiotic, is bactericidal
Gentamicin, an aminoglycoside antibiotic, is bactericidal. Gentamicin passes through the gram-negative membrane in an oxygen-dependent active transport. As oxygen is required, this is why aminoglycosides are not effective in anaerobic bacteria.
Purpose
Bacterial Infection
Ingredients
Gentamicin
Warnings
Ototoxicity has been recorded following the use of gentamicin. Groups at special risk include patients with impaired renal function, infants and possibly the elderly. Consequently, renal, auditory and vestibular functions is advised to be monitored in these patients and serum levels determined so as to avoid peak concentrations above 10mg/l and troughs above 2mg/l when administering Gentamicin twice daily and 1mg/l for a once daily dose.
As there is some evidence that risk of both ototoxicity and nephrotoxicity is related to the level of total exposure, duration of therapy is advised to be the shortest possible compatible with clinical recovery. In some patients with impaired renal function there has been a transient rise in blood-urea-nitrogen which has usually reverted to normal during or following cessation of therapy. It is important to adjust the frequency of dosage according to the degree of renal function.
Gentamicin is advised to only be used in pregnancy if considered essential by the physician .
Side Effects
Vestibular and auditory damage , nephrotoxicity , hypomagnesaemia , blood dyscrasias , purpura , nausea , vomiting , stomatitis , signs of liver dysfunction , antibiotic associated colitis , atrophy at injection site , ototoxicity , neuromuscular blockade.
Storage Instructions
Store this medicine at room temperature, away from direct light and heat.
| Brand | Reckitt |
| Status | Active |
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