Myrin-P Forte Tablets (1 Box = 10 Strips) (1 Strip = 10 Tablets)

It is indicated for the initial intensive phase therapy of new and re-treatment of all forms of tuberculosis in...

PKR 3771.00

PKR 3582.45

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SKU: MYRIN_P_FORTE_TAB_10_10S_NV

Category: Medicines

It is indicated for the initial intensive phase therapy of new and re-treatment of all forms of tuberculosis in category I and II patients caused by susceptible strains of mycobacteria.

Purpose

Tuberculosis

Ingredients

Rifampicin , Isoniazid , Pyrazinamide , Ethambutol

Warnings

Rifampicin/pyrazinamide combination therapy is advised to generally not be offered for treatment of latent tuberculosis infection.
It is not recommended for use in children under 13 years of age since safe conditions of use have not been established. The pyrazinamide inhibits renal excretion of urates, frequently resulting in hyperuricemia that is usually asymptomatic.
Ethambutol hydrochloride may produce decreases in visual acuity which may appear to be due to optic/retrobulbar neuritis. This effect may be related to dose and duration of treatment. This effect is generally reversible when administration of the drug is discontinued promptly. However, irreversible blindness has been reported.

Side Effects

Adverse Reactions Relating to Ethambutol - Blood and Lymphatic System Disorders : Leukopenia, thrombocytopenia, neutropenia. Immune System Disorders : Hypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis) , eosinophilia, and one or more of the following: hepatitis, pneumonitis, nephritis, myocarditis, and pericarditis. Fever and lymphadenopathy may be present. Metabolism and Nutrition Disorders : Anorexia, elevations of serum uric acid concentration. Nervous System Disorders : Dizziness, hypoesthesia, paresthesia. Gastrointestinal Disorders : Epigastric distress, constipation, nausea, vomiting, abdominal pain, anorexia, metallic taste, dry mouth. Skin and Subcutaneous Tissue Disorders : Pruritus, rash, Stevens-Johnson Syndrome, toxic epidermal necrolysis. Musculoskeletal, Connective Tissue and Bone Disorders : Joint pains, acute gout. Respiratory Disorders, Thoracic and Mediastinal Disorders : Pulmonary infiltrates with or without eosinophilia. Adverse Reactions Relating to Rifampicin: Blood and Lymphatic System Disorders : Thrombocytopenia, leukopenia, hemolytic anemia, anemia, eosinophilia. Thrombocytopenia has occurred when ethambutol and rifampicin were administered concomitantly according to an intermittent dose schedule twice weekly and in high doses. Immune System Disorders : Hypersensitivity reactions Metabolism and Nutrition Disorders : Elevations in serum uric acid. Nervous System Disorders : Headache, drowsiness, fatigue, ataxia, dizziness, inability to concentrate, mental confusion, muscular weakness, generalized numbness, pain in the extremities. Adverse Reactions Relating to Isoniazid: Blood and Lymphatic System Disorders : Agranulocytosis, eosinophilia, anemia, thrombocytopenia, methemoglobinemia, vasculitis, lymphadenopathy. Immune System Disorders : Allergic reactions, lupus-like syndrome, rheumatoid syndrome. Hypersensitivity may result in fever, various skin eruptions, hepatitis, rash (including morbilliform, maculopapular, purpuric, and urticarial), vasculitis, and lymphedema. Ear and Labyrinth Disorders : Tinnitus. Metabolism and Nutrition Disorders : Pellagra, hyperglycemia, metabolic acidosis, gynecomastia. Gastrointestinal Disorders : Epigastric distress, nausea, vomiting, constipation. Adverse Reactions Relating to Pyrazinamide : Blood and Lymphatic System Disorders : Thrombocytopenia, sideroblastic anemia with erythroid hyperplasia, vacuolation of erythrocytes, abnormalities in blood clotting mechanisms, porphyria. Immune System Disorders : Hypersensitivity reactions including rash, urticaria, pruritus. Metabolism and Nutrition Disorders : Anorexia, hyperuricemia. Increased difficulty has been reported in controlling diabetes mellitus when diabetics are given pyrazinamide. Gastrointestinal Disorders : Nausea, vomiting. Skin and Subcutaneous Tissue Disorders : Acne, photosensitivity, skin rashes.