Ogrel Plus 81 Tablets 75/81Mg (1 Box = 1 Strip)(1 Strip = 10 Tablets)

Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active...

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SKU: OGREL_PLUS_81MG_TABLETS_2X14S_NV

Category: Medicines

Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets. Aspirin inhibits prostaglandin synthesis resulting in inhibition of platelet aggregation for their lifespan of about 7-10 days. The acetyl group of aspirin binds with a serine residue of cyclooxygenase-1 (COX-1), resulting in irreversible inactivation of the enzyme. Inhibition of COX-1 prevents conversion of arachidonic acid to thromboxane A2 (TXA2), which is a potent agonist of platelet aggregation.

Purpose

Stroke

Ingredients

Aspirin, Clopidogrel

Warnings

Patients is advised to be followed carefully for any signs of bleeding including occult bleeding, especially during the first weeks of treatment and/or after invasive cardiac procedures or surgery. The concomitant administration of Clopidogrel/Aspirin with oral anticoagulants is not recommended since it may increase the intensity of bleeding.
Acquired haemophilia has been reported following use of clopidogrel. In cases of confirmed isolated activated Partial Thromboplastin Time (aPTT) prolongation with or without bleeding, acquired haemophilia is advised to be considered. Patients with a confirmed diagnosis of acquired haemophilia is advised to be managed and treated by specialists, and clopidogrel is advised to be discontinued.
In patients with recent transient ischaemic attack or stroke who are at high risk of recurrent ischaemic events, the combination of ASA and clopidogrel has been shown to increase major bleeding. Therefore, such addition is advised to be undertaken with caution outside of clinical situations where the combination has proven to be beneficial.

Side Effects

Uncommon: Thrombocytopenia, leucopenia, eosinophiliaRare: Neutropenia, including severe neutropeniaVery rare: Thrombotic thrombocytopenic purpura (TTP), aplastic anaemia, pancytopenia, agranulocytosis, severe thrombocytopenia, acquired haemophilia A, granulocytopenia, anaemia