Piozer Plus Tablets 15Mg/500Mg (1 Box = 1 Strip)(1 Strip = 14 Tablets)

Pioglitazone: Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased...

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SKU: PIOZER_PLUS_TABLETS_15500_MG_14S_NV

Category: Medicines

Pioglitazone: Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue. Pioglitazone is a potent and highly selective agonist for peroxisome proliferator-activated receptor-gamma (PPAR?). It improves glycemic control by improving insulin sensitivity at key sites of insulin resistance namely adipose tissues, skeletal muscles and liver. Insulin resistance is known to play a major role in the pathogenesis of type 2 diabetes.Metformin HCl: Metformin HCI is an anti-hyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycemia.

Purpose

Diabetes

Ingredients

Metformin HCl,Â Pioglitazone HCl

Warnings

Pioglitazone, like other thiazolidinediones, can cause fluid retention when used alone or in combination with other anti-diabetic agents, including insulin. Fluid retention may lead to or exacerbate heart failure. If these signs and symptoms develop, the heart failure is advised to be managed according to current standards of care.
Therapy with pioglitazone, like other thiazolidinediones, may result in ovulation in some premenopausal anovulatory women. Thus, adequate contraception in premenopausal women is advised to be recommended while taking Pioglitazone + Metformin HCI.
Patients receiving pioglitazone in combination with insulin or oral hypoglycemic agents may be at risk for hypoglycemia.

Side Effects

Combination therapy: Common: Anemia, visual disturbance, weight increased, arthralgia, headache, hematuria and erectile dysfunction. Uncommon: Flatulence.Individual active substances of the fixed dose combination: Pioglitazone: Common: Upper respiratory tract infection and hypoesthesia. Uncommon: Sinusitis and insomnia.Metformin HCl: Most common: Taste disturbance, nausea, vomiting, diarrhea, abdominal pain and loss of appetite. Uncommon: Decrease in Vitamin B12 absorption and serum levels and lactic acidosis.