Pk-Merz Tablets 100Mg (1 Box = 2 Strips) (1 Strip = 10 Tablets)

Amantadine Sulphate is (I-aminoadamantan) a tricyclic, symmeteric amine with an antiviral activity against RNA & DNA...

PKR 920.00

PKR 874.00

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SKU: PK_MERZ_TABLETS_100_MG_2X10S_NV

Category: Medicines

Amantadine Sulphate is (I-aminoadamantan) a tricyclic, symmeteric amine with an antiviral activity against RNA & DNA viruses. Although exact mode of action of amantadine is not well understood, antiviral activity was found to be related to inhibition of viral uncoating and viral budding by interaction with the viral M2 protein which is a membrane protein. It has established role in influenza and is also used in Parkinsonâ€™s disease as an effective therapeutic agent having antagonistic action on NMDA-ion a channel in basal ganglia which comprehensively improves the troublesome symptom of rigidity, tremor and hypokinesia, particularly the psychic brightening and the increased interest in surrounding.

Purpose

Anti-Parkinson

Ingredients

Amantadine Sulphate

Warnings

In the event of symptoms such as palpitations, dizziness or syncope, treatment with Amantadine Sulphate must be as soon as possible discontinued and the patient checked within 24 hours for QT prolongation. If no QT prolongation is present, treatment with Amantadine Sulphate can be recommenced, taking into account the contraindications and interactions.
Amantadine was found to be embryo toxic and teratogenic. During pregnancy Amantadine is advised to only be used after careful assessment of the risks and benefits.
Amantadine passes into breast-milk. If use during breast feeding is necessary, the infant is advised to be monitored for possible side-effects of the drug (skin rash, urinary retention, vomiting) breast feeding is advised to be discontinued where necessary.

Side Effects

Sleep disturbances, restlessness and agitation. Visual hallucinations may be triggered, particularly in predisposed elderly patients. Occasional dryness of the mouth, constipation, dysuria, central nervous disturbances in older arteriosclerosis patients. Rare reports of cardiac arrhythmias such as ventricular tachycardia, ventricular fibrillation ,QT prolongation etc .