Seretide Evohaler Inhaler 25/250Mcg
Salmeterol: Salmeterol is a selective long-acting (12 hour) ß2 adrenoceptor agonist with a long side chain which binds...
Salmeterol: Salmeterol is a selective long-acting (12 hour) ß2 adrenoceptor agonist with a long side chain which binds to the exo-site of the receptor. The pharmacologic effects of ß2 adrenoceptor agonist drugs, including salmeterol, are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3’,5’-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. Fluticasone propionate: Fluticasone propionate given by inhalation atrecommendeddoses has a glucocorticoid anti-inflammatory action within the lungs, resulting in reduced symptoms and exacerbations of asthma, with less adverse effects than when corticosteroids are administered systemically .
Purpose
Asthma
Ingredients
Salmeterol + Fluticasone Propionate
Warnings
Patients using Salmeterol + Fluticasone propionate inhaler is advised to not use another medicine containing a LABA .
Lower respiratory tract infections, including pneumonia, have been reported in patients with chronic obstructive pulmonary disease (COPD) following the inhaled administration of corticosteroids, including fluticasone propionate. Monitor patients with signs and symptoms of pneumonia.
Orally inhaled corticosteroids may cause a reduction in growth velocity when administered to pediatric patients.
Side Effects
Very common: Headache and nasopharyngitis. Common: Candidiasis of the mouth and throat, pneumonia, bronchitis, hypokalemia, throat irritation, hoarseness/dysphonia, sinusitis, contusions, muscle cramps, traumatic fractures, arthralgia and myalgia. Uncommon: Cutaneous hypersensitivity reactions, respiratory symptoms (dyspnoea), hyperglycemia, anxiety, sleep disorders, tremor, cataract, palpitations, tachycardia, atrial fibrillation and angina pectoris. Rare: Oesophageal candidiasis, angioedema (mainly facial and oropharyngeal oedema), respiratory symptoms (bronchospasm), anaphylactic reactions including anaphylactic shock, cushing''''s syndrome, cushingoid features, adrenal suppression, growth retardation in children and adolescents, decreased bone mineraldensity, behavioural changes, including psychomotor hyperactivity and irritability (predominantly in children), glaucoma, cardiac arrhythmias (including supraventricular tachycardia and extrasystoles) and paradoxical bronchospasm.
Storage Instructions
Store this medicine at room temperature, away from direct light and heat.
| Brand | GSK |
| Status | Active |
Related Products
