Tasmi-Am Tablets 10Mg + 80Mg (1 Box = 2 Strips) (1 Strip = 7 Tablets)

Amlodipine : Amlodipine inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle

PKR 594.00

PKR 564.30

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SKU: TASMI_AM_10_80MG_TAB_14S_NV

Category: Medicines

Amlodipine : Amlodipine inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. It inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Telmisartan : Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis

Purpose

Hypertension

Ingredients

Telmisartan + Amlodipine (As besylate)

Warnings

Close monitoring is required when administering amlodipine in patients with severe aortic stenosis as it may cause acute hypotension.
Particular caution is advised to be exercised when administering the combination of amlodipine and telmisartan to patients with hepatic insufficiency or biliary obstructive disorders.
Hyperkalemia may occur with angiotensin receptors blockers like telmisartan, particularly in patients with advanced renal impairment, heart failure, on renal replacement therapy, or on drugs that increase potassium levels. Periodic determinations of serum electrolytes are recommended to detect possible electrolyte imbalances, particularly in patients at risk

Side Effects

Common Dizziness and peripheral edema. Uncommon Somnolence, migraine, headache, paraesthesia, vertigo, bradycardia, palpitations, hypotension, orthostatic hypotension, flushing, cough, abdominal pain, diarrhea, nausea, pruritis, arthralgia, muscle spasms (cramps in legs), myalgia, erectile dysfunction, asthenia, chest pain, fatigue, edema and increased hepatic enzymes. Rare Cystitis, depression, anxiety, insomnia, syncope, peripheral neuropathy, hypoaesthesia, dysgeusia, tremor, vomiting, gingival hypertrophy, dyspepsia, dry mouth, eczema, erythema, rash, back pain in extremity (leg pain), nocturia, malaise and increase blood uric acid.