Telsarta Tablets 20Mg (1 Box = 1 Strip)(1 Strip = 10 Tablets)

Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II)

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SKU: TELSARTA_TABLETS_20_MG_10S_NV

Category: Medicines

Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation and renal reabsorption of sodium. Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis. Telmisartan has much greater affinity (>3,000 fold) for the AT1 receptor than for the AT2 receptor. Blockade of renin-angiotensin system with ACE inhibitors, inhibits the biosynthesis of angiotensin II from angiotensin I and is widely used in the treatment of hypertension.

Purpose

Hypertension

Ingredients

Telmisartan

Warnings

Patients on dialysis may develop orthostatic hypotension so their blood pressure is advised to be closely monitored. The majority of telmisartan is eliminated in the bile. Patients with biliary obstructive disorders or severe hepatic insufficiency can be expected to have reduced clearance. Telmisartan is advised to be used only with caution in these patients .
There is an increased risk of severe hypotension and renal insufficiency when patients with bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney are treated with medicinal products that affect the reninangiotensin-aldosterone system.
During treatment with medicinal products that affect the renin-angiotensin-aldosterone system hyperkalemia may occur, especially in the presence of renal impairment and/or heart failure. Monitoring of serum potassium in patients at risk is recommended.

Side Effects

Common: Symptoms of infection (e.g., urinary tract infections including cystitis), upper respiratory tract infections including pharyngitis and sinusitis, abdominal pain, diarrhea, dyspepsia, eczema, arthralgia, back pain (e.g., sciatica), muscle spasms or pain in extremity, myalgia, chest pain and influenza-like illness.Uncommon: Anxiety, visual disturbance, vertigo, dry mouth, flatulence, hyperhidrosis and tendonitis.Rare: Stomach discomfort.