Tiovair Rotacaps 18Mcg (1 Box = 3 Strips) (1 Strip = 10 Capsules)

Tiotropium is a long-acting, antimuscarinic agent, which is often referred to as an anticholinergic

PKR 800.00

PKR 760.00

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SKU: TIOVAIR_ROTACAP_18_MCG_30S_NV

Category: Medicines

Tiotropium is a long-acting, antimuscarinic agent, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors, M1 to M5. In the airways, it exhibits pharmacological effects through inhibition of M3-receptors at the smooth muscle leading to bronchodilation. The effect was dose dependent and lasted longer than 24h. The long duration is probably due to the very slow dissociation from the M3 receptor. The bronchodilation following inhalation of tiotropium is predominantly a site-specific effect.

Purpose

Chronic Obstructive Pulmonary Disease

Ingredients

Tiotropium Bromide

Warnings

Immediate hypersensitivity reactions, including urticaria, angioedema (including swelling of the lips, tongue, or throat), rash, bronchospasm, anaphylaxis, or itching, may occur after administration of tiotropium. If such a reaction occurs, therapy with tiotropium is advised to be stopped at once and alternative treatments is advised to be considered.
Inhaled medicines, including tiotropium, may cause paradoxical bronchospasm. If this occurs, it is advised to be treated as soon as possible with an inhaled short acting beta2-agonist such as salbutamol. Treatment with tiotropium is advised to be stopped and other treatments considered.
As a predominantly renally excreted drug, patients with moderate to severe renal impairment (creatinine clearance of <60mL/min) treated with tiotropium is advised to be monitored closely for anticholinergic side effects.

Side Effects

Common: Dry mouth.Uncommon: Dizziness, headache, taste disorders, vision blurred, atrial fibrillation, pharyngitis, dysphonia, cough, gastro-oesophageal reflux disease, constipation, oropharyngeal candidiasis, rash, dysuria and urinary retention.Rare: Insomnia, glaucoma, intraocular pressure increased, supraventricular tachycardia, tachycardia, palpitations, bronchospasm, epistaxis, laryngitis, sinusitis, intestinal obstruction, including ileus paralytic, gingivitis, glossitis, dysphagia, stomatitis, nausea, urticaria, pruritus, hypersensitivity (including immediate reactions), angioedema and urinary tract infection.Not Known: Dehydration, dental caries, anaphylactic reaction, skin infection, skin ulcer, dry skin and joint swelling.