Zestril Tablets 5Mg (1 Box = 1 Strip)(1 Strip = 14 Tablets)
Lisinopril is a peptidyl dipeptidase inhibitor
Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Whilst mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system. Lisinopril is antihypertensive even in patients with low-renin hypertension.
Purpose
Hypertension
Ingredients
Lisinopril
Warnings
Occasionally, blood pressure drops too low after taking lisinopril. This usually happens after the first or second dose or when the dose is increased. It is more likely to occur in those who take diuretics, have a salt-restricted diet, are on dialysis, or are suffering from diarrhoea or vomiting. In patients at increased risk of symptomatic hypotension, initiation of therapy and dose adjustment is advised to be closely monitored.
As with all vasodilators, lisinopril is advised to be given with caution to patients with obstruction in the outflow tract of the left ventricle.
In patients undergoing major surgery or during anesthesia with agents that produce hypotension, lisinopril may blockangiotensin II formation secondary to compensatory renin release. If hypotension occurs and is considered to be due to this mechanism, it can be corrected by volume expansion.
Side Effects
Common: Dizziness, headache, orthostatic effects (including hypotension), cough, diarrhea, nausea, vomiting.Uncommon: Mood alterations, paraesthesia, vertigo, taste disturbance, sleep disturbances, myocardial infarction or cerebrovascular accident, possibly secondary to excessive hypotension in high risk patients, palpitations, tachycardia. Raynaud''''s phenomenon, rhinitis, abdominal pain and indigestion, rash, pruritus, impotence, fatigue, asthenia, increase in blood urea, increase in serum creatinine, increasein liver enzymes, hyperkalaemia.Rare: Decrease in hemoglobin, decrease in hematocrit, mental confusion, dry mouth, hypersensitivity/angioneurotic edema: angioneurotic edema of the face, extremities, lips, tongue, glottis, and/or larynx, urticaria, alopecia, psoriasis, uraemia, acute renal failure.Very rare: Bone marrow depression, anaemia, thrombocytopenia, leucopenia, neutropenia, agranulocytosis, haemolytic anaemia, lymphadenopathy, autoimmune disease, hypoglycemia, bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonia, pancreatitis, intestinal angioedema, hepatitis - either hepatocellular or cholestatic, jaundice and hepatic failure, diaphoresis, pemphigus, toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, oliguria/anuria, gynaecomastia, increase in serum bilirubin, hyponatremia.
Storage Instructions
Store this medicine at room temperature, away from direct light and heat.
| Brand | LCI (UDL) |
| Status | Active |
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